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I declined restating Depakote because of the weight I gained the last time I was on it. 77) and zonisamide (hazard ratio 0. Keppra (levetiracetam) has minimal side effects in people taking it, generally benefit outweighs risk. I have no side effects with lamictal. 75% of reviewers reported a positive effect, while 14% reported a negative effect. The Keppra has the same side-effects as hypoglycemia (low blood sugar) and makes you dizzy and some people have even mention on here that it has caused cholesterol to go up and also tinnitus (ringing in the ears). Topamax has an average rating of 6. Prevents seizures and stabilizes mood. It still beats seizures though so I'll live with it for now 7. Keppra made me have the worst anxiety. 51% of reviewers reported a positive effect, while 30% reported a negative effect.. I'd rather that than more seizures though! 51% of reviewers reported a positive effect, while 30% reported a negative effect I don't know exactly. 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My neurologist thinks that's way too high and doing serious damage to my liver. My name is Evan and I am a 25 year old who was just switched from Keppra to Lamictal for GM seizures. It still beats seizures though so I'll live with it for now I never took Lamictal but my doc said it could make you gain weight. Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms Keppra takes 8 years to come off and Lemectal takes 20 years to kick in. Hello all, just come back from an appointment with my neurologist. I have recently noticed that my memory has gotten worse. They have not controlled my seizures completely, but they have really helped. I've read some of the posts about keppra and they seem pretty scary, but fingers crossed the side. My memory is garbage The Lamictal alone wasn't enough to prevent my seizures, so that's why I'm combining. 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