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These studies aimed to confirm the pharmacokinetic bioequivalence (BE) of FP/S after single doses of Wixela Inhub (test [T]) and Advair Diskus (reference [R]).. Methods: three open-label, randomized, two-way crossover, single-dose studies in healthy subjects ( n = 66 each) compared the systemic exposure of fp and salmeterol after inhalation from three dose strengths of fp/s (100/50, 250/50, or 500/50 μg) delivered from t and r. Advair Diskus is available in the following strengths: 100/50: 100 micrograms fluticasone propionate and 50 mcg salmeterol. The powdered dose is inhaled through the mouthpiece of the Rotahaler. Wixela Inhub ® 100/ 50 mcg (fluticasone propionate and salmeterol inhalation powder, USP) Wixela Inhub ® 250/ 50 mcg (fluticasone propionate and salmeterol inhalation powder, USP). Advair comes in two forms: Advair Diskus and Advair HFA. Advair Diskus inhalation is a steroid and bronchodilator combination medicine that is used to prevent asthma attacks. 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